Research reveals that inflammation-regulating genes also play an important role in maintaining normal blood sugar levels

A study led by researchers at the Garvan Institute of Medicine explores how genes lirais known to regulate inflammation and also plays an important role in maintaining normal blood sugar levels.

The survey results are Diabeteshas implications for the prevention of steroid-induced diabetes, a transient form of diabetes that affects up to half of hospitalized patients treated with high-dose steroids.

Our findings shed new light on the complex network of factors that control glucose metabolism and how it goes wrong in diabetes. Steroids are known to target and prevent inflammation. lira. our findings are lira It also regulates the expression of genes in the pancreas that are essential for glycemic control and diabetes prevention, and thus has major implications for understanding and preventing steroid-induced diabetes. This could potentially be achieved using therapeutic strategies that prevent inflammation without being targeted. lira. “


Professor Shane Gray, senior author and director of Garvan’s Transplantation Immunology Laboratory

Double Duty: lira Genes controlling inflammation and insulin secretion

Inflammation is an important therapeutic target. Inflammation is central to the body’s defense mechanism, but if left unchecked, it can cause harm and autoimmune disease.

To better understand the mechanisms behind inflammation and how to better target it, Garvan-led researchers used mouse models to study different genes that control inflammation in the body. bottom.They discovered an amazing effect – removing a gene called liraIt helped regulate the expression of proteins involved in inflammation, causing abnormally high blood sugar levels.

“When we removed lira The system found the model to be pre-diabetic. We found that this was due to impaired insulin secretion in pancreatic beta cells,” said Nathan Zamit, Ph.D., lead author and visiting researcher at Garvan.

The researchers next investigated the missing cells. lira Utilize next-generation DNA analysis technology.

“Interestingly, we found that proteins lira The product directly turns on the genetic program necessary for pancreatic cells to produce insulin. This is despite the known link between inflammation and diabetes. lira Completely independent control of blood sugar and inflammation.Our findings suggest that lira Even in the absence of inflammation, it plays an important role in keeping blood sugar levels normal,” says Dr. Zamit.

The research team’s findings could lead to more customized treatments for patients who need corticosteroid treatment, a class of drugs commonly used to reduce inflammation in the body for conditions such as arthritis and asthma. influence the development of law;

Patients can develop steroid-induced diabetes within a few weeks of starting or increasing the dose of corticosteroids. Until now, the mechanisms of this association between inflammation and diabetes were poorly understood.

“Our research reveals new and fundamental aspects of how our bodies maintain normal blood sugar levels, but the findings suggest that long-term or high-dose corticosteroid treatment may be necessary. It may also help improve the clinical management of patients with

“By understanding how the pancreatic insulin-producing cells and systems are regulated, liraIt may be possible to balance suppression of inflammation without compromising insulin-producing cell function. This may lead to the development of drugs that reduce inflammation without causing steroid-induced diabetes as a side effect. “

sauce:

Garvan Medical Institute

Reference magazines:

North West Zamit, other. (2023) RELA controls a network of islet-specific metabolic genes required for beta-cell function. Diabetes mellitus. doi.org/10.1007/s00125-023-05931-6.

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